Analgesia and sedation in ICU patients with mechanical ventilation
Conditions
Interventions
Experimental group:Remazolam toluenesulfonic combined with esketamine
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Aged > 18 years; 2.Mechanically ventilated patients admitted to ICU (72 hours >= mechanical ventilation time >= 24 hours); 3.Analgesia and sedation treatment is needed because of the condition; 4.Sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Allergic or contraindicated to benzodiazepines, propofol and other research medicine and components; 2.Patients with a history of opioid abuse; 3.Pregnancy or lactation; 4.Patients with hemodynamic instability, often accompanied by systolic blood pressure less than 90 mmHg; 5.Suffer from mental illness, history of drug use and/or alcohol abuse; 6.Patients with severe central nervous system diseases (such as acute stroke, uncontrolled epilepsy, severe dementia); 7.Patients with intracranial hypertension, acute respiratory distress syndrome, prone ventilation, and other patients who need deep sedation as assessed by the investigator; 8.Severe ventricular dysfunction or II-III °atrioventricular block; HR < 55/min; 9.Acute coronary syndrome (such as unstable angina pectoris, acute myocardial infarction); 10.Researchers think it is not appropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to keep the target sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total amount of sedative and analgesic medicine used to reach the target sedative level for the first time;Total time of mechanical ventilation;Wake up time;Lenth of Hospital Stay; | — |
Countries
China
Contacts
Public ContactChunting Wang
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed