Sepsis
Conditions
Interventions
Experimental group:CVVHDF was administered on the basis of the Chinese Guidelines for the Emergency Treatment of Sepsis/septic shock (2018)
Control group:According to the Chinese Guidelines for emergency management of sepsis/septic shock (2018)
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years; 2.Patients diagnosed with sepsis (meeting the diagnostic criteria defined by Sepsis3.0: infection + organ dysfunction (SOFA score >=2)); 3.Meet cytokine storm criteria; 4.Informed consent signed by the patient or legal guardian.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactation patients; 2.HIV infection and other known immune deficiency patients (use of immunosuppressive drugs, cachexia or end-stage tumors, etc.) and patients with immune diseases such as systemic lupus erythematosus and rheumatoid disease; 3.Patients with existing chronic kidney disease requiring alternative treatment; 4.Patients who are participating in other clinical studies before screening; 5.Combined with uncontrollable bleeding or combined with blood transfusion reaction; 6.Other conditions that the researchers considered inappropriate for inclusion, such as: terminal state of chronic disease, no cure or survival possibility of discharge; Assess patients whose condition requires blood purification as a treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical index;Incidence of secondary organ failure;Days in intensive care;Use of vasoactive agents in intensive care units;Duration of mechanical ventilation during intensive care;Sequential organ failure score; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day survival rate; | — |
Countries
China
Contacts
Public ContactTang Zhanhong
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed