Esketamine for continuous intravenous analgesia after spinal orthopedic surgery: a randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053088

Enrollment

Unknown

Registered

2021-11-10

Start date

2020-10-16

Completion date

Unknown

Last updated

2021-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after spinal orthopedic surgery

Interventions

Group I:sufentanil 2ug/kg

Group II:sufentanil 2 µg/kg+esketamine 0.25 mg/kg

Group III:sufentanil1.5ug/kg+esketamine0.25kg/kg

Eligibility

Sex/Gender

All

Age

16 Years to 84 Years

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologist classes I–III; 2. Body mass index < 30 kg/m2.

Exclusion criteria

Exclusion criteria: 1. Patients with severe cardiopulmonary dysfunction; 2. Patients with a history of allergy to the drugs used; 3. Patients who used sedative and analgesic drugs recently; 4. Patients with a history of alcohol and drug abuse; 5. Patients with acute hemorrhage and hemodynamic instability during surgery; 6. Patients who need mechanical ventilation support after surgery.

Design outcomes

Primary

Measure	Time frame
The pain numerical rating scale (NRS) score;Ramsay sedation score;The total number of patient-controlled analgesia (PCA) compressions;	—

Secondary

Measure	Time frame
Blood gas analysis;lactic acid values;the heart rate;mean arterial pressure;pulse oxygen saturation;	—

Countries

China

Contacts

Public ContactPeng Yue

The Eighth Affiliated Hospital of Sun Yat-Sen University

hg_84396959@sina.com+86 15986686015

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026