Effects of positive end-expiratory pressure and oxygen concentration on non-hypoxemic apnea time during induction of general anesthesia

Effects of positive end-expiratory pressure and oxygen concentration on non-hypoxemic apnea time during induction of general anesthesia: A randomized controlled trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053037

Enrollment

Unknown

Registered

2021-11-10

Start date

2021-11-11

Completion date

Unknown

Last updated

2022-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of Anestheisa

Interventions

Hypoxia without PEEP group:FiO2=0.6, PEEP=0

Hypoxia with PEEP group:FiO2=0.6, PEEP=6

Pure oxygen without PEEP group:FiO2=1, PEEP=0

Pure oxygen with PEEP group:FiO2=1, PEEP=6

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA classification I-II; 2. Aged 18-80 years; 3. 18kg/m^2 <= BMI <= 35kg/m^2; 4. Patients undergoing elective general anesthesia without nasogastric tube.

Exclusion criteria

Exclusion criteria: 1. Those who refuse to participate in the experiment and do not sign the informed consent form; 2. The patient has symptoms of upper respiratory tract infection or pulmonary infection in the past 4 weeks, and chest X-ray shows pneumonia; 3. Diseases affecting thoracic and lung compliance such as chicken breast, pectus excavatum, chest trauma and surgical history, chronic obstructive pulmonary emphysema, pleural effusion and acute respiratory distress syndrome; 4. A history of neuromuscular dysfunction; 5. There are serious cardiovascular events, lung, kidney and hematopoietic system diseases; 6. Patients who have received general anesthesia in the previous 7 days; 7. Patients with mental system diseases and cognitive impairment; patients with a history of abuse of psychotropic drugs and narcotic drugs; 8. For those who are expected to be difficult to intubate, the main factors include: obesity, short neck, nail-mind spacing III, etc.; 9. Hemoglobin < 90g/L; 10. Other conditions that the investigator judges that the patient is not suitable to participate in the clinical trial.

Design outcomes

Primary

Measure	Time frame
non-hypoxemic apnea time;	—

Secondary

Measure	Time frame
Oxygenation Index;Oxygenation recovery time;	—

Countries

China

Contacts

Public ContactZhang Changsheng

Anesthesia and Operation Center, The First Medical Center of Chinese PLA General Hospital

powerzcs@126.com+86 10 66938152

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026