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Application of esketamine on brachial plexus block anesthesia and it's effect on rebound pain after peripheral nerve block: a randomized controlled trial

Application of esketamine on brachial plexus block anesthesia and it's effect on rebound pain after peripheral nerve block: a randomized controlled trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100053035
Enrollment
Unknown
Registered
2021-11-10
Start date
2021-11-12
Completion date
Unknown
Last updated
2022-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopaedic upper limb surgery

Interventions

RNK group:Ultrasound guided single supraclavicular brachial plexus block with 0.375% ropivacaine + 0.5 mg / kg esmketamine 30ml
R group:Ultrasound guided single supraclavicular brachial plexus block with 0.375% ropivacaine 30ml

Sponsors

Xuzhou Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 16-60 years; 2. Body mass index 20-26 kg/m^2; 3. American Society of Anesthesiologists (ASA) classification: I-II; 4. Patients undergoing upper arm, forearm and hand surgery; 5. Agree to receive ultrasound-guided supraclavicular brachial plexus block anesthesia; 6. Patients with sufficient Chinese language ability and a clear understanding of the Numerical Rating Scale (NRS) of pain, who can cooperate with patients in pain assessment; 7. Patients and their families understand and voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of chronic pain or long-term use of sedative and analgesic drugs; 2. Patients with a history of neurological, psychiatric or neuromuscular diseases; 3. Patients with multiple injuries requiring other surgery or pain medication; 4. Patients with preoperative nerve injury; 5. Patients with known hypersensitivity to ropivacaine or esketamine and chronic pain reliever users; 6. Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure over 180/100mmHg); 7. Untreated or undertreated hyperthyroidism (hyperthyroidism) patients.

Design outcomes

Primary

MeasureTime frame
Onset time of sensory block;

Secondary

MeasureTime frame
Heart rate, mean arterial pressure, pulse oxygen, respiratory rate;Incidence of adverse reactions;Postoperative NRS pain score;Incidence of rebound pain;Dosage of sufentanil in PCIA pump after operation;PCIA pump effective press and total press times;Onset time of motor block;Duration of block;

Countries

China

Contacts

Public ContactZhu Shiyao

Xuzhou Cancer Hospital

476113149@qq.com+86 13852155340

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026