Effect of esketamine for erector spinal block on postoperative delirium in elderly patients undergoing chest surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100053032

Enrollment

Unknown

Registered

2021-11-10

Start date

2021-11-09

Completion date

Unknown

Last updated

2022-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic surgery

Interventions

experimental group:Esmketamine and Ropivacaine

control group:Ropivacaine

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective thoracic surgery; 2. Aged over 65 years; 3. ASA I-II grade.

Exclusion criteria

Exclusion criteria: 1. Preoperative history of mental illness such as cerebral infarction, schizophrenia, epilepsy, depression, etc.; 2. Combined with a history of severe cardiovascular and cerebrovascular diseases; 3. Severe liver and kidney damage; 4. Severe hearing and visual impairment; 5. Long-term use of narcotic analgesics, sedative-hypnotics; 6. Preoperative MMSE score 30kg/m^2); 13. Patients with high intracranial pressure or intraocular pressure; patients with hyperthyroidism.

Design outcomes

Primary

Measure	Time frame
Incidence of delirium;	—

Secondary

Measure	Time frame
Vital signs at different time points;Dosage of general anesthetics propofol and remifentani;Recovery time;Postoperative pain VAS score, Ramsay score, effective pressing times of analgesic pump and remedial times during rest and cough;IL-1ß, NSE, TNF-a;length of hospital stay;Postoperative recovery quality;	—

Countries

China

Contacts

Public ContactZhu Shanshan

Xuzhou Cancer Hospital

582024178@qq.com+86 15895218633

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026