Psoriasis
Conditions
Interventions
Sponsors
The First Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
4 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Aged 4 to 18 years; 2. Patients with severe psoriasis (the definition of severe psoriasis meets at least one of the following): (1) Physician's Global Assessment Index (PGA) >= 4; (2) Involved area > 20% body surface area (BSA), or involved area > 10% BSA combined with very thick skin lesions; (3) (Psoriasis Area and Severity Index) PASI > 20, or PASI > 10 combined with at least one of the following: (4) Active psoriatic arthritis does not respond to non-steroidal anti-inflammatory drugs; (5) Children's Dermatology Life Quality Index (CDLQI) > 10; (6) Clinically relevant facial, genital or hand and/or foot involvement; 3. Have not used biological agents before.
Exclusion criteria
Exclusion criteria: 1. Patients participating in other clinical trials; 2. Those who are in the period of systemic acute or chronic infection, or have a history of active tuberculosis or hepatitis in the past; 3. Malignant tumor subjects; 4. Patients with severe heart, liver, kidney and other organs and systemic diseases; 5. There are cases where other investigators consider it inappropriate to use the test drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with >=75% decrease in Psoriasis Area and Severity Index scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with psoriasis area and severity index of 50/90;Physician's Global Assessment ;Body Surface Area;modified Body Mass Index ; | — |
Countries
China
Contacts
Public ContactGao Xinghua
The First Affiliated Hospital of China Medical University
Outcome results
None listed