Gastrointestinal dysfunction
Conditions
Interventions
Propofol + remifentanil group:intravenous injection of propofol and remifentanil
Propofol +nalbuphine group:intravenous injection of propofol and nalbuphine
Propofol +oxycodone group:intravenous injection of propofol and oxycodone
Propofol + dezocine group:intravenous injection of propofol and dezocine
Propofol + butorphanol group:intravenous injection of propofol and butorphanol
Propofol + sufentanil group:intravenous injection of propofol and sufentanil
Propofol + fentanil group:intravenous injection of propofol and fentanil
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Outpatients proposed to undergo gastroscopy; 2. Aged 18-60 years; 3. ASA Grade I or II; 4. No serious liver or kidney dysfunction; 5. 18.5 <= BMI < 30kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Patients with acute upper gastrointestinal bleeding resulting in hemorrhagic shock and unstable blood pressure; 2. Preoperative assessment of potentially difficult airways (history of difficult airways, sleep apnea syndrome, abnormal head and neck mobility, nail and chin spacing less than 6.5cm, mouth opening less than 3 horizontal fingers, Mallampati grade greater than 3); 3. Presence of airway hyperresponsiveness (asthma, COPD, long-term smoking history); 4. Diseases of the central nervous system or cardiovascular system (including pre-existing or existing hypertension, coronary heart disease, valvular disease, cardiomyopathy, arrhythmia, heart failure, diabetes, stroke, aneurysm); 5. A history of drug allergy related to the study; 6. Drugs that may alter the pharmacodynamics and pharmacokinetics of the drugs under study are being used (including benzodiazepines;Other analgesic drugs, such as NSAIDS and tramadol;Other a2 adrenergic receptor agonists, such as Clonidine;Drugs that affect hemodynamics, such as antihypertensive drugs and digitalis); 7. A history of drug or alcohol addiction; 8. Severe anemia; 9. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective sedation during diagnosis and treatment; | — |
Countries
China
Contacts
Public ContactCheng Wei
Huai'an First People's Hospital
Outcome results
None listed