Muscle Cramps in Patients with Maintenance Hemodialysis
Conditions
Interventions
Group A:1-4 weeks of oral administration of Shaoyao Gancao Decoction (plain granules of boiled decoction pieces)
Group B:1-4 weeks as a blank control group
7-10 weeks of oral administration of Shaoyao Gancao Decoction (Zhisan Decoction Pieces Extract Granules)
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with chronic kidney disease stage 5 and maintenance hemodialysis for more than 3 months; 2. Patients with dialysis times >= 2 times/week and muscle cramps >= 2 times/week (or >= 4 times in 2 weeks); 3. Aged 18 to 80 years(calculated according to the age when informed consent was obtained), those who signed the informed consent form; 4. Patients who can receive oral test drugs.
Exclusion criteria
Exclusion criteria: 1. Patients with serious complications (liver, heart, lung, blood, metabolic diseases or malignant tumors, etc.); 2. Patients with chronic cardiac insufficiency grade 3 (NYHA classification) or above; 3. Pregnancy and patients who may be pregnant; 4. Patients with combined hepatocellular carcinoma. However, if the disease is controllable after treatment, it does not constitute an exclusion condition; 5. Patients who have recently taken drugs related to muscle spasm (the washout period should be more than 2 weeks); 6. Patients who are considered to be unable to comply with the principles of alcohol abstinence during participation in this study; 7. Patients with a history of allergy to Kampo medicines; 8. Patients who are or plan to participate in drug clinical trials or other clinical studies; 9. Other patients who are considered inappropriate by the doctor in charge of the research or the doctor in charge of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement in the frequency of muscle cramps; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degrees of pain during muscle cramps;blood routine examination ;liver function;renal function;Myocardial enzyme;Hypersensitive troponin ;Blood electrolyte;Electrocardiogram; | — |
Countries
China
Contacts
Public ContactMao Wei
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed