Effect of Esketamine Hydrochloride on Haemodynamic Changes after Tracheal Intubation without Muscle Relaxants: A Randomized Controlled Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052973

Enrollment

Unknown

Registered

2021-11-06

Start date

2021-11-08

Completion date

Unknown

Last updated

2022-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

esketamine group:esketamine combined with remifentanil

propofol group:propofol combined with remifentanil

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Thyroidectomy patients receiving neuroelectrophysiological monitoring; 2. Aged 20-60 years; 3. ASA classification I-II; 4. Body mass index (BMI): 18-30 kg/m^2; 5. The patients were tested voluntarily and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Severe cardiovascular disease (NYHA III-IV) or severe arrhythmia; 2. Patients with impaired liver function and/or renal function (ALT and/or AST exceed 2 times the upper limit of normal, BUN and/or SCr exceed 1.5 times the upper limit of normal; 3. Those with a history of asthma or airway hyperresponsiveness; 4. Those who have used sedatives or anesthetics within 24 hours; 5. Patients with mental disorders or mental illnesses; 6. Patients predicted to be difficult airway; 7. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure;Diastolic blood pressure;mean arterial blood pressure;Heart rate;	—

Secondary

Measure	Time frame
Tracheal intubation conditions;RASS score in PACU;	—

Countries

China

Contacts

Public ContactDu Fang

Zhongshan Hospital, Fudan University

du.fang@zs-hospital.sh.cn+86 13917569701

Outcome results