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Effect of TBS on aphasia after stroke and the mechanism of brain remodeling based on resting-state fMRI

Effect of TBS on aphasia after stroke and the mechanism of brain remodeling based on resting-state fMRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100052962
Enrollment
Unknown
Registered
2021-11-06
Start date
2021-12-09
Completion date
Unknown
Last updated
2022-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

cTBS group:cTBS stimulus
sham group:cTBS sham group

Sponsors

Wuxi Tongren Rehabilitation Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. In patients with ischemic stroke confirmed by brain CT or MRI, the lesions are all in the left cerebral hemisphere cortex; 2. The first onset, a single lesion, within 45 days of the first part of the disease course, and the second part without course limitation; 3. Patients with non-fluid aphasia were assessed according to the Western Aphasia Battery (WAB); 4. Aged 50-75 years; 5. The native language is Chinese; 6. Primary school and above culture; 7. Right-handed; 8. The language function was normal before the onset; 9. Be informed about the repeat transcranial magnetic stimulation treatment and brain imaging scanning procedure in this study, and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who cannot cooperate with examination and treatment; 2. Speech disorders caused by other neurodegenerative diseases such as dementia, Parkinson's disease, and motor neuron disease; 3. Combined with a history of epilepsy, drug abuse or mental illness; 4. There are metal foreign bodies in the body or other electronic devices implanted in the body.

Design outcomes

Primary

MeasureTime frame
Western aphasia test;Resting state fMRI related indicators;

Secondary

MeasureTime frame
Psychological language assessment of Chinese aphasia;BDAE Aphasia severity Scale;

Countries

China

Contacts

Public ContactRen Caili

Wuxi Tongren Rehabilitation Hospital

sally7226@163.com+86 15306175051

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026