Neuromyelitis Optica Spectrum Disorders
Conditions
Interventions
Gold Standard:Cell-based assay (CBA) for antibody testing as recommended.
Index test:Matrix-assisted 
desorption/ionization 
(MALDI 
MS) 
is 
responsible 
for 
the 
obtainment 
of 
biofluid 
fingerprints, 
further 
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. AQP4 antibody-positive NMOSD patients all meet the 2015 IPND diagnostic criteria, namely: (1) AQP4 antibody serologically positive; (2) At least one core symptom; (3) Exclude the possibility of other diseases; 2. Patients with MOG antibody disease all meet the 2018 expert consensus diagnostic criteria, namely: (1) Monophasic or recurrent acute optic neuritis, myelitis, brainstemitis, brainstem encephalitis, encephalitis, or any combination of the above; (2) MRI or electrophysiological results suggest demyelination of the central nervous system; (3) MOG-IgG serology was positive by CBA method.
Exclusion criteria
Exclusion criteria: Patients with missing or incomplete clinical information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| area under curve; | — |
Countries
China
Contacts
Public ContactGuan Yangtai
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed