End-stage renal disease
Conditions
Interventions
Elective general surgery group in supine position:medical treatement
Renal transplantation Group(S group):medical treatement
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing emergency kidney transplantation under general anesthesia (creatinine clearance CLCR=80ml/min); 2. Aged 18 to 65 years; 3. ASA classification I ~ III.
Exclusion criteria
Exclusion criteria: 1. Suffering from neuromuscular disease, liver dysfunction, heart disease and personal or family history of malignant hyperthermia; 2. Pregnant or breastfeeding women; 3. Difficult airway, sleep apnea syndrome and body mass index >= 28kg/m^2; 4. Patients who have taken the following drugs recently: aminoglycoside antibiotics, anticonvulsants, magnesium, and perioperative toremifene, fusidic acid and flucloxacillin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average time from start of dosing to recovery of T4/T1 ratio to 0.7, 0.8, 0.9;Residual muscle relaxation, including hypoxemia, TOF ratio < 0.9, head-up < 5 seconds; | — |
Countries
China
Contacts
Public ContactTang Yiyang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed