Obesity
Conditions
Interventions
Experimental group(high dose):polyethylene glycol loxenatide 400ug
Experimental group(low dose):polyethylene glycol loxenatide 300ug
Control group:none
Sponsors
The First Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 16 to 65 years; 2. Simple obesity and BMI >= 50 kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Intellectual disability or mental illness; 2. Pregnant or breastfeeding; 3. Taking medications known to affect weight within the past 6 months; 4. History of previous bariatric surgery; 5. Severe obesity complications cannot participate in preoperative weight intervention; 6. History of gastrointestinal diseases such as gastroduodenal ulcer and pancreatitis; 7. Participate in conflicting research protocols.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EWL%>=60% at 12 months after SG operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight loss effects and tolerability and safety of polyethylene glycol losenatide;Remission of obesity complications;ICU occupancy;operation time; | — |
Countries
China
Contacts
Public ContactHu Sanyuan
The First Affiliated Hospital of Shandong First Medical University
Outcome results
None listed