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Efficacy and safety of mTORi in the treatment of secondary immune thrombocytopenia

Efficacy and safety of sirolimus in the treatment of secondary immune thrombocytopenia

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100052913
Enrollment
Unknown
Registered
2021-11-06
Start date
2022-09-28
Completion date
Unknown
Last updated
2023-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

secondary immune thrombocytopenia, sITP

Interventions

experimental group:sirolimus and dexamethasone
control:steroid

Sponsors

The Second Affiliated Hospital of Army Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 30 x 10^9 / L with severe organ bleeding; 3. Understand the research procedure and voluntarily sign the informed consent in writing.

Exclusion criteria

Exclusion criteria: 1. Severe heart, kidney or liver insufficiency; 2. Women who are pregnant or breastfeeding; 3. Combined with other serious diseases such as hypertension, diabetes, gastric ulcer; 4. Patients with contraindications to the use of hormones and sirolimus; 5. Suffering from lung infection and serious infection in other parts of the body; 6. Those with large wounds or unhealed incisions on the whole body; 7. Those who cannot be followed up as scheduled; 8. The researchers believe that other reasons are not suitable for clinical trials.

Design outcomes

Primary

MeasureTime frame
overall response rate;

Secondary

MeasureTime frame
Adverse Events;

Countries

China

Contacts

Public ContactFeng Yimei

Department of Hematology, Second Affiliated Hospital of Army Military Medical University

yimeifeng@163.com+86 23 68763198

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026