An open-label, single-center, randomised controlled trial comparing the effects of the glucagon-like peptide 1 receptor agonist semaglutide versus bariatric surgery on remission of diabetes in obese type 2 diabetes patients

Effects of the glucagon-like peptide 1 receptor agonist semaglutide versus bariatric surgery on remission of diabetes in obese type 2 diabetes patients: an open-label, single-center, randomised controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052902

Enrollment

Unknown

Registered

2021-11-06

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes mellitus

Interventions

Surgery group:metabolic surgery

GLP-1 group:giving glucagon-like peptide 1 receptor agonist semaglutide

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged 18 to 60 years who had been diagnosed with type 2 diabetes within the past 5 years, had a body-mass index of 27.5-32.5 kg/m2, and were receiving metformin alone or without any diabetes medications.

Exclusion criteria

Exclusion criteria: 1. Severe liver and kidney disease (eGFR<60ml/min), malignant tumor, thyroid, Cushing's syndrome and other endocrine diseases; 2. Acute coronary syndrome, uncontrolled heart failure, weight loss of more than 10Kg in the past 6 months.

Design outcomes

Primary

Measure	Time frame
a HbA1C level of 6.5% or less with or without the use of diabetes medications for more than3 months;	—

Secondary

Measure	Time frame
body fat percentage;fasting blood glucose less than 7mmol/L;blood pressure;weight;levels of lipids;urine albumin creatine ratio;ophthalmologic outcomes;adverse events;quality of life;	—

Countries

China

Contacts

Public ContactMeng Hua

China-Japan Friendship Hospital

menghuade@hotmail.com+86 18611457779

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026