Sepsis
Conditions
Interventions
Control group:Wear an ear stimulator, but do not give electrical stimulation
AVNS(auricular vagus nerve stimulation) group:Auricular vagus nerve stimulation
Sponsors
Qilu Hospital of Shandong University (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Sepsis patients who were diagnosed with sepsis 3.0 standards, the time of admission was less than one week after onset; 2. Stay in ICU is expected to be longer than 1 week; 3. Aged >= 18 years, no gender limitation; 4. The patients voluntarily or their family members agreed to participate in the study and signed the informed consent of the study.
Exclusion criteria
Exclusion criteria: 1. Sepsis patients with multiple organ failure, especially those with severe impairment of heart, liver and kidney function; 2. People who are known to be overly sensitive to AVNS, have a history of allergy or intolerance to AVNS; 3. Local skin infection and electrode cannot be placed; 4. Patients with cardiac pacemakers or implanted defibrillators; 5. Patients in pregnancy and lactation; 6. Those who are participating in other clinical trials; 7. Patients unable to maintain a resting state (such as epilepsy, Parkinson's disease).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum TNF-a levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum IL-1ß?IL-6?IL-8?IL-4?CitH3 and IL-10 levels;Other inflammatory indicators (CRP, PCT, etc.);SOFA score and APACHE II score; | — |
Countries
China
Contacts
Public ContactWu Zhiyang
Qilu Hospital of Shandong University (Qingdao)
Outcome results
None listed