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The value and safety of levothyroxine replacement therapy in elderly hypothyroidism complicated with depression: a prospective study

The value and safety of levothyroxine replacement therapy in elderly hypothyroidism complicated with depression: a prospective study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052884
Enrollment
Unknown
Registered
2021-11-06
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly hypothyroidism complicated with depression

Interventions

Hypothyroidism group:No
Subclinical hypothyroidism group(thyroid stimulating hormone >= 10mIU/ L):No
Subclinical hypothyroidism group(TSH < 10mIU/ L):No
Control group:No

Sponsors

The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Sign informed consent; 2. Hypothyroidism or subclinical hypothyroidism, aged 60 and above, regardless of gender; 3. Hamilton Depression Scale score over 20.

Exclusion criteria

Exclusion criteria: 1. Did not take antithyroid drugs or undergo thyroid surgery; 2. Brain diseases, mental diseases, malignant tumors, severe myocardial ischemic diseases, etc.

Design outcomes

Primary

MeasureTime frame
Thyroid function;The score of Hamilton Depression Scale;Resting-state fMRI;—

Secondary

MeasureTime frame
The score of Hamilton Anxiety Scale;—

Countries

China

Contacts

Public ContactSun Yan

The First Affiliated Hospital of Anhui Medical University

1184559005@qq.com+86 13856072956

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026