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Early Prediction of Acute Coronary Syndrome Risk in Stable Coronary Heart Disease by Traditional Chinese Medicine Syndrome Elements Combined with Anxiety/Depression Assessment: A Prospective Cohort Study

Early Prediction of Acute Coronary Syndrome Risk in Stable Coronary Heart Disease by Traditional Chinese Medicine Syndrome Elements Combined with Anxiety/Depression Assessment: A Prospective Cohort Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052872
Enrollment
Unknown
Registered
2021-11-16
Start date
2022-01-01
Completion date
Unknown
Last updated
2022-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome

Interventions

Sponsors

Zhujiang Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. History of stale heart attack or coronary angiography confirmed at least one coronary artery stenosis >= 50%; 2. The patient was clinically asymptomaticstable angina pectoris or acute coronary syndrome over 1 month stable condition; 3. Aged 30-75 years; 4. Volunteer to participate in and cooperate with the study, sign the informed consent, complete the diagnosis information, and be able to determine the syndrome elements.

Exclusion criteria

Exclusion criteria: 1. Chest pain caused by myocarditis, cardiac neurosis, gastroesophageal reflux, cervical spondylosis, hyperthyroidism, intercostal neuralgia; 2. Patients with severe hypertension, severe arrhythmia, severe cardiopulmonary insufficiency, stroke, nephritis, renal failure, rheumatism, liver, kidney, hematopoietic system, endocrine system and other serious diseases and osteoarthropathy; 3. Patients with acute infection (within 4 weeks) and who are taking antibiotics; 4. Patients during pregnancy or lactation or with allergic constitution; 5. Previous history of mental illness, dementia, alcohol or drug dependence; 6. Taking anti-anxiety and depression drugs; 7. Patients with poor compliance, and unable to communicate normally.

Design outcomes

Primary

MeasureTime frame
Elements of TCM syndrome;Anxiety/depression state;Blood pressure;History of diabetes;Blood fat (total cholesterol, high-density lipoprotein, low density lipoprotein, triglyceride);Left ventricular hypertrophy;Smoking history;Fasting plasma glucose;New or recurrent ACS(Acute Coronary Syndrome);SEN(sensitivity), SPE(specificity), ACC(accuracy), AUC(area under curve) of ROC(receiver operating characteristic curve);

Secondary

MeasureTime frame
Myocardial enzyme (creatine kinase isoenzyme, creatine kinase, lactic dehydrogenase, aspartate transferase, a-hydroxybutyric dehydrogenase);Troponin;Myohemoglobin;HCY(homocysteine);Interleukin-6;Hypersensitive C-reactive protein;

Countries

China

Contacts

Public ContactLiang Donghui

Zhujiang Hospital of Southern Medical University

dhliang79@smu.edu.com+86 13189097991

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026