Allergic rhinitis
Conditions
Interventions
Group B:Nasal irrigation and Biroph
Group C:Nasal cavity irrigation and conventional treatment
Group D:Nasal cavity irrigation, conventional treatment and Biroph
Sponsors
Children's Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 3 years, and < 18 years, no gender limit; 2. Meet the diagnostic criteria of the 2010 Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in Children; 3. The course of allergic rhinitis is more than half a year; 4. The volume of adenoids accounts for <= 70% of the nasopharynx; 5. Have not used anti-allergic drugs such as glucocorticoids, antihistamines, leukotriene receptor antagonists in the past 2 weeks; 6. The children and their guardians have good compliance, can cooperate with drug treatment for 1 to 3 months, voluntarily participate in this clinical study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Have had nasal surgery, nasal deformities, etc.; 2. With nasal polyps, asthma, nasal septum deviation and other causes of nasal congestion; 3. Acute upper respiratory tract infection in the past 2 weeks; 4. Related metabolic disorders, cardiovascular diseases, nervous system diseases, blood system diseases, gastrointestinal diseases, cerebrovascular diseases and respiratory diseases, etc.; 5. Subjects with severe liver and kidney dysfunction and allergies; 6. Subjects deemed unsuitable by other researchers to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum immunoglobulin total IgE, IgA, IgG, IgM;Number and percentage of eosinophils;Lymphocytes CD3, CD16, CD56, CD19, CD8, CD4;Cytokines IL2, IL4, IL6, IL10, TNF, INF-r levels; | — |
Countries
China
Contacts
Public ContactFu Yong
Children's Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed