Neonatal Respiratory Distress Syndrom
Conditions
Interventions
HFOV group:Invasive high-frequency oscillatory ventilation
HFOV-VG group:high-frequency oscillatory ventilation combined with volume-guarantee
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Newborns diagnosed with respiratory distress syndrome within 12 hours after birth and requiring tracheal intubation for high-frequency oscillatory ventilator treatment; 2. Gestational age >= 28 weeks; 3. Patients who started receiving non-invasive ventilation within 12 hours after birth, but changed to invasive high-frequency oscillatory ventilation within 3 days after birth; 4. The children's family members agreed to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Complex congenital heart disease, congenital gastrointestinal malformations, congenital airway malformations, congenital nervous system malformations, genetic metabolic diseases, genetic diseases, etc.; 2. Severe asphyxia and aEEG still abnormal or accompanying with obvious symptoms of neurological damage at 72 hours after birth; 3. With various reasons of shock, anti-shock treatment was unsuccessful pesisting for half an hour.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bronchopulmonary dysplasia;Death at 36 gestatinal weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraventricular hemorrage;Periventricular white matter softening; | — |
Countries
China
Contacts
Public ContactShi Yuan
Children's Hospital of Chongqing Medical University
Outcome results
None listed