Cardiac surgery
Conditions
Interventions
General anesthesia cardiac surgery group:No
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-85 years, gender is not limited; 2. Patients undergoing cardiac surgery in Qilu Hospital of Shandong University from January to October 2021 under general anesthesia (tracheal intubation and mechanical ventilation); 3. ASA I-IV; 4. Clearly understand and voluntarily participate in the research, and sign the informed consent form by themself or their legal guardian.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to general anesthesia; 2. Patients who have used sedative and analgesic drugs within 24 hours or narcotic drugs within 5 days, and benzodiazepine sleeping pills or opioid analgesics within the last 6 months; 3. Patients with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accident, and central nervous system diseases; mental system diseases (schizophrenia, mania, bipolar disorder, insanity, etc.), long-term history of taking psychotropic drugs and cognitive dysfunction; 4. History of drug abuse and alcohol abuse within 2 years prior to the beginning of the screening period. Alcohol abuse means drinking more than 2 units of alcohol per day on average (1 unit = 360 mL beer or 45 mL 40% alcohol white wine or 150 mL wine); 5. Pregnant or lactating women; 6. Allergic or contraindicated to benzodiazepines, opioids, propofol, etomidate, rocuronium, atropine and their components; 7. Patients diagnosed as having difficulty in respiratory management: Modified Mallampati score IV; 8. Participated in drug clinical trials as a subject within the last 3 months; 9. Patients deemed unsuitable for the trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Judgment of clinical outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay;Length of ICU(intensive care unit) stay;Depth of anesthesia;Intraoperative hemodynamic indexes; | — |
Countries
China
Contacts
Public ContactFang Ningning
Qilu Hospital of Shandong University
Outcome results
None listed