residual neuromuscular blockade, RNMB
Conditions
Interventions
Group A:Neostigmine 0.04 mg / kg was given when TOFC=0
Group B:Neostigmine 0.06 mg / kg was given when TOFC=0
Group C:Neostigmine 0.04 mg / kg was given when TOFR=0.4
Group D:Neostigmine 0.04 mg / kg was given when TOFR=0.4
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.The range of body mass index (BMI) is 18.5 ~ 25 kg / m2; 2.Aged 18 ~ 65 years; 3.ASA I ~ III; 4.Patients undergoing gastrointestinal surgery under elective Intravenous Inhalation Combined with general anesthesia.
Exclusion criteria
Exclusion criteria: 1. History of allergic diseases, mental illness and alcoholism; 2. Long term use of psychotropic drugs and chronic analgesic drugs; 3. Patients with neuromuscular diseases and using drugs that can affect neuromuscular conduction function; 4. Severe heart, brain, liver, kidney, lung and endocrine diseases (cardiac function above grade II, liver function above child Pugh grade A, renal function above ckd1 stage, moderate and severe pulmonary ventilation dysfunction), electrolyte disorder, anemia (HB < 70g / L) and severe infection; 5. Patients whose muscle relaxation monitoring is affected by trauma, surgical history, hypoplasia and deformity at the muscle relaxation monitoring site; 6. Those who are allergic or contraindicated to the drugs in this study; 7. Participants in other drug clinical studies in the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TOFR(train-of-four stimulation ratio); | — |
Countries
China
Contacts
Public ContactSu Min
The First Affiliated Hospital of Chongqing Medical University?
Outcome results
None listed