Small cell lung cancer
Conditions
Interventions
Therapy group:Carbon ion irradiation and drug therapy
Sponsors
Wuwei Tumor Hospital Heavy Ion Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years; 2. Pathology confirmed small cell lung cancer; 3. Local radiotherapy of lung lesions was not performed in the patients with the limited-stage; 4. Have not had chest radiation therapy; 5. Renal function, liver function and bone marrow function are basically normal(serum creatinine 9.5 g/dL; WBC >= 3000/mL; PLT >= 100000/mL); 6. ECOG general status score less than or equal to 2; 7. The anticipated survival will be >= 6 months; 8. Informed consent was signed by the patient or his/her legal representative before radiotherapy.
Exclusion criteria
Exclusion criteria: 1. Patients cant hold their positions for more than 30 minutes; 2. Tumor progression extensively involving the pleura and cancerous pleural effusion; 3. Lose more than 20% of body weight within six months; 4. During pregnancy(confirmed by serum or urine beta-HCG test) or lactation; 5. Drug abuse or alcohol dependence; 6. AIDS; 7. With uncontrolled systemic or pulmonary or cardiac disease; 8. With serious comorbidities that preclude the successful implementation of the trial protocol, including uncontrolled comorbidities (pulmonary insufficiency, cardiovascular, lung, liver, kidney, diabetes, etc.), addiction and/or mental illness; 9. Implantation of a pacemaker or other metal prosthesis can be enough to affect the recipient of radiation therapy; 10. Patients with poor compliance, including those who may not be able to complete treatment plans or receive required follow-up and examinations; 11. has a history of other malignancies(skin cancer and stage 0 cervical cancer have been cured are excluded); 12. Systemic immunotherapy or corticosteroid therapy; 13. Serum creatinine clearance < 30 mL/minutes; 14. There are contraindications to radiation therapy; 15. Participated in clinical trials of other drugs within 30 days prior to enrollment in this trial; 16. Incapacity for civil conduct or limited capacity for civil conduct; 17. Any medical history that in the investigator's judgment may interfere with trial results or increase patient risk; 18. Any conditions that the physician deems inappropriate for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival;Local control rate;Objective response rate;Incidence of toxic reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Failure mode of tumor treatment;Overall survival;Relationship between toxicity and dose/volume of irradiated organs at risk; | — |
Countries
China
Contacts
Public ContactZhang Yanshan
Wuwei Tumor Hospital Heavy Ion Center
Outcome results
None listed