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Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformations

Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformations

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100052762
Enrollment
Unknown
Registered
2021-11-05
Start date
2021-11-01
Completion date
Unknown
Last updated
2022-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Verrucous Venous Malformation

Interventions

group 1:topical sirolimus

Sponsors

Shanghai Ninth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients with verrucous venous malformation who came to the outpatient department of our hospital from Nov. 2021 to June 2022 had no complications such as ulcers, infection, and bleeding on the surface of the lesions; 2. Diffuse lesions; 3. Patients who have not received oral sirolimus treatment before the initial diagnosis, and have not received laser or external drug treatment at the lesion; 4. Those who are willing to accept and cooperate with examination and treatment, and who can follow up regularly.

Exclusion criteria

Exclusion criteria: 1. The patient has severe immunodeficiency or congenital disease; 2. Pregnant patients and the elderly (> 65 years old); 3. Patients with severe keratinization at the lesion, which cannot be treated by drugs or lasers, or the lesion has affected the function of the limbs and other patients who need surgical resection; 4. Those who are participating in other clinical trials; 5. Those who are allergic to sirolimus.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale;

Countries

China

Contacts

Public ContactLin Xiaoxi
linxiaoxi@126.com+86 13701997136

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026