None listed
Conditions
Interventions
No opioid anesthesia group under ERAS concept:Esketamine-Dexmedetomidine
Opioid anesthesia group under ERAS concept:Sufentanil-Remifentanil
Opioid-free anesthesia group:Traditional Treatment - Esketamine - Dexmedetomidine
Opioid anesthesia group:Traditional Treatment - Sufentanil - Remifentanil
Sponsors
Hefei Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Gynecological patients undergoing laparoscopic surgery, ASA anesthesia grade I-II; 2. Aged 20-60 years; 3. Patients voluntarily participated in this study and signed informed consent before surgery; 4. The patient has no language, intelligence, and comprehension impairments and can communicate normally; 5. The patient has no history of neuropsychiatric disorders, drug dependence and alcoholism; 6. The patient had no serious cardiovascular and cerebrovascular disease or major organ dysfunction before surgery.
Exclusion criteria
Exclusion criteria: Patients allergic to anesthetics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia, surgery, orientation recovery time;Visual Analogue Score (VAS);Postoperative adverse reaction;Patient Health Questionnaire Depression Self-rating Scale Score;GAD-7 Anxiety Self-Rating Scale Score;Plasma brain-derived neurotrophic factor;Serotonin;C-reactive protein;Cortisol;Gut microbiota;Pain mediators (PEG2, SP, ß-EP);Pittsburgh Sleep Quality Index Scale Score;First time of postoperative exhaust and defecation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;Intraoperative dosage; | — |
Countries
China
Contacts
Public ContactChen Liang
Hefei Hospital Affiliated to Anhui Medical University
Outcome results
None listed