Atrial fibrillation
Conditions
Interventions
Experimental group:Dronedarone Hydrochloride Tablets
Sponsors
Shenzhen Hospital, Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-75 years diagnosed with persistent atrial fibrillation with a duration of <3 years; 2. All patients received catheter ablation and recovered sinus rhythm after ablation; 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of allergy to dronedarone or amiodarone; 2. Patients with New York Heart Association class III/IV heart failure or recent cardiac decompensation requiring hospitalization; 3. First-degree AV block with PR interval > 280 ms, or second- or third-degree AV block, or patients with sick sinus syndrome (unless a pacemaker is installed); 4. Patients with bradycardia (average heart rate = 500 ms, or concomitant use of medicinal or natural medicines that prolong the QT interval and may increase the risk of torsades de pointes, such as phenothiazine antipsychotics, tricyclic antidepressants, some oral macrolide antibiotics; 7. Liver function: AST and ALT > 2.5 times the upper limit of normal; total bilirubin > 1.5 times the upper limit of normal; previous hypersensitivity pneumonitis or interstitial pneumonitis associated with amiodarone use; 8. Amiodarone was used within 4 weeks before ablation, or other antiarrhythmic drugs were discontinued for less than 5 half-lives before ablation; 9. Severe electrolyte abnormalities (serum potassium <3.5mmol/L, serum magnesium <0.75mmol/L); 10. Obstructive/occult obstructive hypertrophic cardiomyopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first recurrence of atrial fibrillation/atrial tachycardia within 3 months after surgery lasted > 30 seconds; | — |
Secondary
| Measure | Time frame |
|---|---|
| Atrial fibrillation (AF) load;Assessment of quality of life in patients with atrial fibrillation.; | — |
Countries
China
Contacts
Public ContactYao Yan
Shenzhen Hospital, Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed