postoperative delirium
Conditions
Interventions
Sponsors
Guangzhou Medical University Affiliated Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 60-90 years who underwent elective lung surgery or mediastinal esophagus surgery. Surgical types include: lung wedge resection, segmentectomy, lobectomy, sleeve lung resection, pneumonectomy, mediastinal tumor resection and diagnostic pleurectomy, radical esophagectomy, there are no restrictions on surgical methods (thoracotomy or VATS); 2. Surgery and general anesthesia time >= 2 hours, postoperative hospital stay at least 7 days; 3. No severe visual or auditory impairment, able to read text for neurobehavioral tests; 4. The patients participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The score of the Simple Intelligence Scale Test (MMSE) is lower than 23; 2. Past history of dementia, mental illness or other central nervous system diseases; 3. Inability to understand Mandarin or Cantonese; 4. Those who are allergic to esketamine or dexmedetomidine; 5. Patients with intracranial hypertension, glaucoma and hyperthyroidism; 6. Patients with sick sinus syndrome, second-degree or higher atrioventricular block or sinus bradycardia (HR200/110mmHg); 11. ASA IV or V level.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative cognitive function;emergency delirium;pain numeric rating score;postoperative cognitive function;acetylcholine;brain derived neurotrophic factor (BDNF); | — |
Countries
China
Contacts
Public ContactYao Yonghua
Guangzhou Medical University Affiliated Cancer Hospital
Outcome results
None listed