sepsis
Conditions
Interventions
Group 1:Water sanitizer enema
Group 2:Physiological saline enema
Sponsors
Dongfang Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, no gender limit. 2. The diagnostic criteria for sepsis in the new 2016 SSC guidelines are: infection-induced organ dysfunction, SOFA score (Table 2-1) increased by >= 2 points from baseline, for patients without underlying organ dysfunction, the baseline for SOFA is 0; The diagnostic criteria for septic (septic) shock are: on the basis of a clear diagnosis of sepsis, accompanied by persistent hypotension, and on the basis of adequate blood volume replenishment, vasopressors are still required to maintain mean arterial pressure >= 65 mmHg and serum lactate levels > 2 mmol/L (18 mg/dL). 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Massive blood loss, acute bleeding, anemia (Hb = 20mg/day; 11. The investigator evaluates that the patient is unable or unwilling to comply with the requirements of the research protocol; 12. Patients with intestinal obstruction, intestinal perforation, colon cancer and rectal cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| procalcitonin;IL-6;C-reactive protein;TNF-a;lactic acid;IL-8;gut microbiota; | — |
Countries
China
Contacts
Public ContactLiao Lijun
Outcome results
None listed