Pretreatment with esketamine for reduction of propofol injection pain: a randomized placebo-controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052742

Enrollment

Unknown

Registered

2021-11-04

Start date

2021-11-05

Completion date

Unknown

Last updated

2022-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

normal saline group:Pretreating normal saline 30 seconds before propofol injection

lidocaine group:Pretreating 40 mg lidocaine 30 seconds before propofol injection

esketamine group:Pretreating 0.15mg/kg esketamine 30 seconds before propofol injection

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. All patients have ASA grades I-II; 2. Aged 18 to 65 years; 3. Patients who plan to undergo tympanoplasty under elective general anesthesia; 4. Informed and agreed to the research and signed the consent form.

Exclusion criteria

Exclusion criteria: 1. Those who are allergic to experimental drugs; 2. Those with severe risk of elevated blood pressure or intracranial pressure; 3. Hypertension (blood pressure at rest>170/100); 4. Hyperthyroidism; 5. Serious insufficiency of important organs; 6. Patients with obvious ischemic heart disease; 7. Sinus tachycardia; 8. Abuse of alcohol or analgesic, sedative, antidepressant drugs.

Design outcomes

Primary

Measure	Time frame
the incidence of pain on propofol injection;	—

Secondary

Measure	Time frame
the severity of propofol-induced injection pain;the vital signs within 5 minutes after induction;cumulative dosages of vasoactive drugs within 5 minutes after induction;the adverse events related to drugs;	—

Countries

China

Contacts

Public ContactJia Ji'e

jiajie@eentanesthesia.com+86 13641839213

Outcome results