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Efficacy and safety of controlled hypotension during general anesthesia in reducing perioperative blood loss in DDH patients undergoing total hip arthroplasty

Efficacy and safety of controlled hypotension during general anesthesia in reducing perioperative blood loss in DDH patients undergoing total hip arthroplasty

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100052734
Enrollment
Unknown
Registered
2021-11-04
Start date
2021-12-01
Completion date
Unknown
Last updated
2022-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

end-stage congenital dysplasia of the hip

Interventions

controlled hypotension anesthesia group 1:Intraoperative mean arterial pressure 70 - 80 mmHg
controlled hypotension anesthesia group 2:Intraoperative mean arterial pressure < 70 mmHg
normol tension group:General anesthesia

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-80 years, gender is not limited; 2. Total hip replacement due to end-stage DDH disease; 3. The American Society of Anesthesiologists (ASA) grades are I-III; 4. Patients with or without controlled blood pressure during the perioperative period; 5. Patients undergoing general anesthesia surgery.

Exclusion criteria

Exclusion criteria: 1. Combined with severe cerebrovascular accident and neurological disease; 2. Complined with severe cardiovascular disease and liver and kidney insufficiency; 3. Combined with severe anemia, hypovolemia and coagulation dysfunction; 4. Complined with resistant hypertension and peripheral vascular disease.

Design outcomes

Primary

MeasureTime frame
Total perioperative blood loss;Dominant blood loss;Hidden blood loss;Transfusion rate;Transfusion volume;

Secondary

MeasureTime frame
Duration of surgery/anesthesia;Complications;Postoperative liver and kidney function;Incidence of acute myocardial injury;Incidence of acute kidney injury;Incidence of postoperative hypotension;

Countries

China

Contacts

Public ContactZeng Yi

West China Hospital, Sichuan University

zengyigd@126.com+86 18980602289

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026