Bipolar disorder and depression
Conditions
Interventions
Depression group:rTMS treatment
Bipolar disorder group:rTMS treatment
Sponsors
Xiamen Xianyue Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Depressive disorder group: (1) Han nationality, aged 18-60 years, primary school or above; (2) Right-handed; (3) Meet the diagnostic criteria for unipolar depression in DSM-V; (4) According to the Hamilton score, the severity of depression was rated as mild to moderate (8 points <= HAMD 24 < 35 points); (5) No antidepressant treatment within 1 month before enrollment; (6) Participate voluntarily and sign the informed consent. 2. Bipolar disorder group: (1) Han nationality, aged 18-60 years, primary school or above; (2) Right-handed; (3) Meet the diagnostic criteria for bipolar disorder (depressive episode phase) in DSM-V; (4) According to the Hamilton score, the severity of depression was rated as mild to moderate (8 points<=HAMD24<35 points); (5) No anti-bipolar disorder drug treatment within 1 month before enrollment; (6) Participate voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe physical diseases (such as severe heart, brain, liver, kidney insufficiency, etc.); 2. Patients with organic brain diseases (such as trauma, tumors, etc.); 3. There are peripheral nerve and muscular system lesions; 4. Suffering from other mental illnesses (such as schizophrenia, bipolar disorder, obsessive-compulsive disorder, etc.); 5. History of alcohol abuse or psychoactive substance abuse; 6. Patients who are pregnant or breastfeeding; 7. Patients with visual and hearing impairments; 8. Contraindications to rTMS treatment, including metal implants or risk of epilepsy; 9. Repeated suicidal thoughts, or any suicidal behavior, the third item in HAMD24 >= 3 points; 10. Patients who are participating in other clinical trials; 11. The researchers believe that other reasons are not suitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Near infrared spectroscopy detection;Event related potential ;Trail Making Test Parts A & B;The Stroop Color and Word Test ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD) 24 items; | — |
Countries
China
Contacts
Public ContactXia Yuping
Xiamen Xianyue Hospital
Outcome results
None listed