Osteoarthritis of the knee
Conditions
Interventions
Group B:Acetaminophen
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need unilateral primary total knee arthroplasty (TKA) due to severe knee osteoarthritis; 2. Aged 18 to 80 years; 3. The preoperative American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) was I to III.
Exclusion criteria
Exclusion criteria: 1. Patients with heart, lung and other important organ failure; 2. Abnormal liver and kidney function (ALT, AST> 1.5 times the normal value, blood BUN > -8.3 mmol/L, blood Scr > 115 umol/L); 3. Diabetic patients with poor control of blood sugar levels, who are judged by the researchers to be at risk of infection; 4. Combined with disturbance of consciousness or mental illness; 5. Have a history of open knee surgery; 6. Neuromuscular dysfunction affects lower extremity function; 7. Patients with severe coagulation disorders; 8. Combined with severe medical or surgical diseases or weak constitution, unable to tolerate surgery; 9. Severely unstable and incurable with ligament-preserving TKA; 10. Active infection foci in the body (systemic or local infection lesions); 11. Severe osteoporosis, metabolic bone disease, radiation bone disease, tumor around the knee joint; 12. Patients in family planning, lactation and pregnancy during the entire clinical research period; 13. Those who have participated in other clinical trials within 3 months; 14. The investigator believes that it is not suitable to participate in this clinical trial due to other reasons; 15. Knee flexion deformity >= 30 degree or varus deformity >= 30 degree; 16. Those who are allergic to the drugs used in this study; 17. Opioid addicts; 18. Those with language barriers and those who cannot complete the Visual analogue scale (VAS) for pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dosage of morphine hydrochloride injection for postoperative salvage; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time to first postoperative remedial analgesia;Postoperative visual analogue scale pain score;American hospital for special surgery knee score;Range of knee motion;Daily walking distance;Postoperative inflammatory markers;Hospital stay;Incidence of complications; | — |
Countries
China
Contacts
Public ContactKang Pengde
West China Hospital, Sichuan University
Outcome results
None listed