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Correlation between serum sVCAM1 levels after laparotomy and the incidence of perioperative cognitive dysfunction in patients with colorectal tumors

Correlation between serum sVCAM1 levels after laparotomy and the incidence of perioperative cognitive dysfunction in patients with colorectal tumors

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100052711
Enrollment
Unknown
Registered
2021-11-04
Start date
2021-11-01
Completion date
Unknown
Last updated
2022-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Neurocognitive Disorder

Interventions

case series:None

Sponsors

The Fourth Affiliated Hospital of Harbin Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with colorectal tumors who are scheduled to undergo laparotomy; 2. According to the American Society of Anesthesiologists (ASA) classification, it is classified as I-III; 3. With the consent of the hospital ethics committee, the patients participated voluntarily and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Suffering from multiple sclerosis; 2. Suffering from various autoimmune diseases; 3. Suffering from diabetes; 4. Current infection (determined by clinical status, CRP and white blood cell count); 5. Severe visual or hearing impairment and MMSE score below 18; 6. History of alcohol or drug dependence, or taking psychotropic substances.

Design outcomes

Primary

MeasureTime frame
Soluble vascular cell adhesion molecule 1;Simple Mental State Examination Scale;

Secondary

MeasureTime frame
Age;Body mass index;American Society of Anesthesiologists (ASA) Classification;Anesthesia and operation time;Intraoperatve blood loss;Intraoperative urinary volume;Intraoperative infusion volume;Intraoperative blood transfusion volume;Medications in operation;

Countries

China

Contacts

Public ContactLi Chenglong

The Fourth Affiliated Hospital of Harbin Medical University

934105818@qq.com+86 13204608551

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026