Breast Cancer
Conditions
Interventions
case series:None
Sponsors
Yunnan Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patient is female, aged >=18 years; 2. ECOG score 0-1 points; 3. Unilateral or bilateral primary invasive carcinoma of the breast confirmed by biopsy pathology; 4. Immunohistochemistry (IHC) suggests HER-2 positive (HER-2+++ or HER-2++ and FISH amplification); 5. According to the current American Joint Cancer Committee (AJCC) breast cancer staging criteria for patients with I-III based on radiological and/or clinical assessment; 6. According to NCCN guidelines, the patients have received neoadjuvant chemotherapy including anthracyclines and taxanes and targeted therapy of more than 4 cycles of trastuzumab + pertuzumab or only trastuzumab; 7. Modified radical mastectomy or breast-conserving radical mastectomy for breast cancer has been completed, and the postoperative pathological examination results have been reported.
Exclusion criteria
Exclusion criteria: 1. After lumpectomy or minimally invasive atherectomy; 2. Received endocrine therapy or castration therapy in the past; 3. Incomplete baseline information or immunohistochemical results; 4. History of other malignant tumors; 5. Patients with severe cardiac insufficiency, liver and kidney insufficiency, active mental system diseases (schizophrenia, severe depression, bipolar affective disorder, etc.); 6. Those who are unwilling to sign the informed consent; 7. Persons without full capacity for civil conduct; 8. In the investigator's opinion, other conditions make them unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological complete response rate; | — |
Countries
China
Contacts
Public ContactChen Wenlin
Yunnan Cancer Hospital
Outcome results
None listed