PLA2R-negative membranous nephropathy
Conditions
Interventions
Experimental group:mercury detoxification and general non-immunotherapy
Control group:no mercury detoxification, only general non-immunotherapy
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with renal pathology consistent with membranous nephropathy who were admitted to the Department of Nephrology, Peking University First Hospital; 2. People at high risk of mercury poisoning, such as those who often use whitening and freckle-removing products, traditional Chinese medicine remedies containing mercury, hair dyeing patients, barbers, long-term consumption of seafood, and long-term living in areas with high PM2.5 before kidney damage, have been tested for urinary mercury Concentration 25g/L.
Exclusion criteria
Exclusion criteria: 1. Patients with positive PLA2R antigen staining in renal tissue and/or serum anti-PLA2R antibody; 2. Patients with other secondary membranous nephropathy such as lupus nephritis, hepatitis B virus-related nephritis, hepatitis C virus-related nephritis, tumor-related nephropathy, etc.; 3. Patients with acute kidney injury; 4. Severe, disabling or life-threatening nephrotic syndrome; 5. Received glucocorticoid and/or immunosuppressive therapy within the past 6 months; 6. History of allergy to sodium dimercaptopropanesulfonate; 7. Patients without renal biopsy; 8. Pregnant or lactating women and patients under the age of 18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the 24h urine protein;serum albumin; | — |
Countries
China
Contacts
Public ContactZhou Fude
Peking University First Hospital
Outcome results
None listed