Type 1 diabetes
Conditions
Interventions
Experimental group:intensive insulin therapy combined with autologous Treg transfusion
Control group:intensive insulin therapy alone
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
12 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the 1999 WHO diagnostic criteria for diabetes; 2. Agd 12 to 65 years; 3. At least one islet autoantibody positive and/or fasting C-peptide does not exceed 300pmol/L; 4. I and my family members or legal guardians voluntarily accept and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. The condition of diabetic ketoacidosis has not been controlled; 2. Severe allergic constitution; 3. Known or suspected tumor; 4. Acute pancreatitis, and severe heart, liver, kidney, rheumatic immune, respiratory, nervous or infectious diseases; 5. Suffering from gestational diabetes mellitus, single gene mutation diabetes mellitus, diabetes mellitus caused by pancreatic damage or other secondary diabetes mellitus (such as diabetes mellitus caused by Cushing's syndrome, thyroid dysfunction or acromegaly, etc.); 6. Women who are pregnant or have a pregnancy plan before and after treatment, and women who are breastfeeding; 7. Mental illness, alcohol or drug abuse, unable to cooperate with treatment; 8. According to the judgment of the investigator, there are other clinical conditions that may endanger the safety of the subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of clinical remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effects;HbA1c;serum C peptide; | — |
Countries
China
Contacts
Public ContactZhu Dalong
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Outcome results
None listed