Perioperative and postoperative analgesic effect of puerpera
Conditions
Interventions
Control group:10ml normal saline was injected intravenously after delivery
Experimental group1:0.15mg/kg of esketamine which was diluted to 10ml was injected intravenously after delivery
Experimental group2:0.25mg/kg of esketamine which was diluted to 10ml was injected intravenously after delivery
Sponsors
The Fourth Hospital of Shijiazhuang
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. ASA class II; 2. Before starting the activities related to the trial, voluntarily sign the informed consent form and fully understand the purpose and significance of this trial, and voluntarily abide by this trial procedure; 3. Subjects who plan to elective cesarean section under continuous spinal-epidural anesthesia; 4. Aged 18 to 40 years; 5. The estimated duration of surgery is less than or equal to 2 hours; 6. Post-pregnancy and prenatal body mass index (BMI) < 35kg/m2.
Exclusion criteria
Exclusion criteria: 1. There are contraindications to continuous spinal-epidural anesthesia (such as history of central nervous system infection, spinal cord or spinal canal disease or history of surgery, systemic infection, skin or soft tissue infection at puncture site, coagulation disorders); 2. Those with a history of stroke, cognitive impairment and epilepsy; 3. Those who have a history of myocardial infarction, angina pectoris, or a history of serious arrhythmia such as second-degree or higher atrioventricular block within 6 months before screening; 4. Pregnancy complicated with other diseases (malignant tumor, gestational hypertension, abnormal thyroid function, etc.); 5. In the non-oxygen state, the peripheral blood oxygen saturation (SpO2) is less than 92%; 6. Continuous use of sedatives, analgesics and hypnotics for 3 months before randomization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire-9 score;Heart rate;Ramsay sedation score;Edinburgh Postpartum Depression Scale score; | — |
Countries
China
Contacts
Public ContactChen Hongzhuan
The Fourth Hospital of Shijiazhuang
Outcome results
None listed