premature ovarian insufficiency,POI
Conditions
Interventions
premature ovarian insufficiency group:None
Perimenopause group:None
normal control group:None
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Early-onset ovarian insufficiency group: 1. Aged 25IU/L; 3. Natural menopause aged > 45 years. Perimenopause group: 1. The mother's menstrual cycle is regular and the age of menopause is >=40 years old; 2. If there are children, the children will develop normally during puberty and have regular menstruation. Normal control group: 1. Aged less than 40 years; 2. Premenopausal; 3. Normal menstrual regularity (menstrual cycle is 21-35 days, menstrual period is 2-8 days); 4. Normal menstrual flow and normal blood FSH level; 5. The mothers menstrual cycle is regular and the age of menopause is greater than or equal to 40 years old. If there are children, the children will develop normally during puberty and have regular menstruation.
Exclusion criteria
Exclusion criteria: 1. History of chemotherapy, radiotherapy, autoimmune diseases, primary or metastatic ovarian tumors, pelvic and ovarian inflammatory diseases, and pelvic or ovarian surgery; 2. Have a family history of reproductive-related diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| body fat percentage;bone density; | — |
Countries
China
Contacts
Public ContactLi Bin
Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed