anesthesia
Conditions
Interventions
control group :propofol
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, gender is not limited; 2. ASA grades are grades I to III; 3.18 kg/m2 <= BMI <= 30kg/m2; 4. Subjects who need elective day surgery under general anesthesia and need tracheal intubation; 5. The subjects voluntarily participated in this trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to general anesthesia; 2. Those who plan to undergo general intravenous anesthesia and need to combine other anesthesia methods, such as inhalation anesthesia, spinal anesthesia, nerve block, etc.; 3. Associated with infectious heart diseases such as myocarditis or endocarditis, sepsis; 4. People with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, history of cerebrovascular accident and central nervous system diseases: mental system diseases (schizophrenia, mania, insanity, etc.) and long-term use of psychiatric drugs Drug history, or other diseases that prevent the measurement of BIS values; 5. Acute heart failure, unstable angina, myocardial infarction within 6 months before screening, resting ECG heart rate = 450ms, female >= 470ms; 6. Abnormal liver and kidney function (ALT or AST >= 2.5 times the upper limit of normal, TBIL >= 1.5 times the upper limit of normal), abnormal renal function (BUN or Urea >= 1.5 times the upper limit of normal, Cr > the upper limit of normal, or 28 years before surgery Dialysis treatment within the past few days), or patients with obvious abnormal coagulation function (PT/APTT/TT higher than the upper limit of normal), anemia or thrombocytopenia (Hb = 160 mmHg, and/or diastolic blood pressure DBP >= 100 mmHg during the screening period); 8. Sitting systolic blood pressure SBP= 11.1 mmol/L during screening period, and/or random blood glucose >= 13.6 mmol/L); 10. History of drug and alcohol abuse within 2 years before the start of the screening period, and alcohol abuse is defined as regular drinking more than 14 times/week (1 time = 150 ml of wine or 360 ml of beer or 45 ml of spirits); 11. Subjects who are judged to have difficulty in airway management, the modified Markov score is grade IV; 12. Known or suspected allergic or contraindicated to various components of the study drug or other benzodiazepines, opioids, propofol, muscle relaxants, etc.; 13. Pregnant or lactating women or subjects (including men) who have childbearing plans within 6 months; 14. Those who have participated in any clinical trial as subjects within 3 months before enrollment; 15. Other conditions judged by the investigator to be unsuitable for inclusion.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The time between the start of medication and the loss of consciousness;bispectralindex values;Time between the end of administration and the patient's awakening;Injection pain score;Extubation time after administration;Anesthesia satisfaction; | — |
Primary
| Measure | Time frame |
|---|---|
| Ratio of successful induction and maintenance of anesthesia; | — |
Countries
China
Contacts
Public ContactHu Yanhui
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed