Postoperative cognitive dysfunction
Conditions
Interventions
Experimental group:Inject ropivacaine hydrochloride 10ml (100mg) + 2% lidocaine 10ml for block
Control group:general anesthesia
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged > 65 years, gender is not limited; 2. Patients undergoing elective thoracoscopic lobectomy; 3. ASA score I-III; 4. Fluent in communication, able to complete the self-assessment scale independently; 5. All patients were screened with the MMSE scale before surgery, and the Mini Mental State Scale (MMSE) score was >24 and there was no cognitive function problem; 6. Voluntarily participate and sign the informed consent form, and be able to comply with the research visit plan and other program requirements.
Exclusion criteria
Exclusion criteria: 1. Dementia; 2. Have a history of alcohol or drug abuse; 3. Congenital mental retardation or a history of mental illness; 4. Patients with neurological diseases that can cause brain dysfunction; 5. Long-term use of sedative or psychotropic drugs; 6. Local anesthetic allergy; 7. Those who participated in other clinical trials in the past three months; 8. Re-intubation after operation, or unplanned re-operation; 9. Have serious medical diseases, such as heart failure, acute myocardial infarction, respiratory failure, renal failure and liver failure; 10. History of chronic pain, or preoperative chest puncture positioning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cognitive dysfunction in elderly patients 7 days after surgery or before discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of delirium 1-5 days after surgery;Incidence of chronic cognitive dysfunction in postoperative patients;Recovery quality score;Changes in perioperative blood sugar;Intraoperative and postoperative adverse events; | — |
Countries
China
Contacts
Public ContactShi Hong
Shanghai Pulmonary Hospital
Outcome results
None listed