postoperative cognitive dysfunction
Conditions
Interventions
POCD group vs. non POCD group:Nil
Sponsors
Department of anesthesia and perioperative medicine, the Second Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. No gender restriction, aged 65 to 85 years; 2. ASA classification II to III; 3. No liver and kidney dysfunction; 4. No history of taking psychotropic drugs within half a year before admission; 5. Able to correctly understand the contents of the Mini-mental State Examination (MMSE), with a preoperative MMSE score of >=23.
Exclusion criteria
Exclusion criteria: 1. People with central nervous system diseases, taking sedatives and antidepressants; 2. Severe organ dysfunction; 3. Severe cerebrovascular disease, cerebral metabolic disease, history of dementia, etc., alcoholics who drink for a long time; 4. Severe visual or hearing impairment or those who cannot communicate with the visitors due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Intelligence Mental State Examination Scale score;Wechsler Adult Memory Scale;China revised Wechsler Adult Intelligence Scale;Trail Making Test;Functional Magnetic Resonance results;Z scoring results;Results of computerized neurocognitive function evaluation system; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic information of the patient;Drug dosage;Intraoperative blood loss;Rehydration volume;Spontaneous breathing recovery time;Extubation time;surgery informaton;Hemodynamic indexes; | — |
Countries
China
Contacts
Public ContactHu Xianwen
Department of anesthesia and perioperative medicine, the Second Hospital of Anhui Medical University
Outcome results
None listed