Colorectal cancer
Conditions
Interventions
Case series:NA
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Clinical stage II (cT3-4N0M0) colorectal adenocarcinoma and mucinous adenocarcinoma; 2. Aged 18 to 70 years; 3. The selection must be the first diagnosis of colorectal cancer and no previous history of other malignant tumors; 4. Have not received neoadjuvant therapy; 5. Able to provide MMR or MSI diagnostic report; 6. The NCCN guidelines on clinical high-risk factors (T stage, histological differentiation, vascular invasion, nerve invasion, intestinal obstruction, tumor site perforation, positive surgical margins, and safe margins) can be obtained from pathology reports and medical records. , the number of lymph nodes sent for examination); 7. Can provide the following paraffin pathological specimens: 1) The pathological specimen number matches the clinical patient information; 2) 2 paraffin sections with a thickness of 50 µm and 4 paraffin sections with a thickness of 5 µm; 3) The content of tumor tissue in the section is not less than 50%, and the proportion of necrotic tissue is less than 10%; 4) Paraffin tissue is not stained. 8. Patients voluntarily participated in this study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. After pathological diagnosis, the pathological stage of the tumor is not stage II (pT3-4N0M0); 2. Colorectal cancer cases whose pathological types are not adenocarcinoma and mucinous adenocarcinoma; 3. The test result of microsatellite instability is MSI-H or dMMR; 4. Pregnant or lactating women; 5. Any other factors that the researcher believes may affect the results of the study or lead to the termination of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA Ploidy;Tumor stroma; | — |
Countries
China
Contacts
Public ContactWang Xishan
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed