Acute postoperative pain
Conditions
Interventions
experimental group:Esketamine injection was used in the perioperative period
control group:Esketamine hydrochloride injection was not used during perioperative period
Sponsors
The General Hospital of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years, no gender limit; 2. Plan to carry out selective general anesthesia, lower gastrointestinal surgery, gynecological surgery, urological surgery, thoracic surgery, orthopedic limb surgery, orthopedic spine surgery or surface surgery (thyroid or breast surgery), head and neck surgery; 3. ASA score I-III; 4. Sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. Expected hospital stay < 48h; 2. Patients who are expected to enter ICU after surgery; 3. Patients who are expected to return to the ward with a tracheal tube after the operation; 4. Those who are known to be allergic to the active ingredients or excipients of esketamine hydrochloride injection; 5. Patients with severe disturbance of consciousness or mental system diseases (schizophrenia, mania, bipolar disorder, mental confusion, etc.) and cognitive dysfunction; 6. A history of severe cardiovascular disease (congestive heart failure, severe angina pectoris, or unstable angina or myocardial infarction occurred within 6 months); 7. Patients during pregnancy or lactation; 8. Patients with MMSE score <18 points; 9. Patients who have any of the following contraindications for esketamine injection: (1) Patients who are at serious risk of increased blood pressure or intracranial pressure; (2) Patients with high intraocular pressure (glaucoma) or penetrating eye trauma; (3) Poorly controlled or untreated hypertensive patients (arterial hypertension, resting systolic blood pressure exceeding 180 mmHg, or resting diastolic blood pressure exceeding 100 mmHg); (4) Patients with untreated or undertreated hyperthyroidism (hyperthyroidism).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs and physical examination;Pain assessment;Depression/anxiety assessment;Delirium assessment;Cognitive function assessment;laboratory examination; | — |
Countries
China
Contacts
Public ContactLi Mingqiang
Xiangyang Central Hospital
Outcome results
None listed