Helicobacter pylori infection
Conditions
Interventions
7-day vonoprazan group:vonoprazan 20mg,2 times a day for 7days
14-day vonoprazan group:vonoprazan 20mg,2 times a day for 14 days
14-day rabeprazole group:rabeprazole 10mg,2 times a day for 14 days
Sponsors
Department of Gastroenterology, Jinshan Hospital of the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 20 to 70 years; 2. Gastroscopy showed chronic gastritis; 3. After 13C breath test or biopsy of gastric mucosa under gastroscope, Helicobacter pylori infection was found; 4. Sign informed consent; 5. Did not participate in other research projects in recent three months.
Exclusion criteria
Exclusion criteria: 1. History of receiving H.pylori eradication therapy; 2. Those who had received antibiotics, bismuth and PPI within 4 weeks; 3. Acute upper gastrointestinal bleeding, acute gastric mucosal lesions, gastroesophageal reflux, peptic ulcer, gastrinoma, Zollinger-Ellison syndrome, patients who have undergone surgery (upper gastrointestinal resection or vagotomy) that may affect gastric acid secretion, or other patients with gastric acid secretion disorder; 4. Accompanied by serious or unstable heart, liver, kidney, endocrine, blood and other physical diseases or malignant tumors; 5. Those who allergy to any of the study drugs; 6. Those who had used drugs that had an impact on the efficacy evaluation before treatment; 7. Lactation, pregnancy or planned pregnancy during the trial period; 8. Patients with severe cognitive impairment and not cooperating with treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rates of H. pylori; | — |
Countries
China
Contacts
Public ContactGu Sai
Jinshan Hospital, the First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed