Chronic Thromboembolic Pulmonary Hypertension
Conditions
Interventions
Control group:Traditional simple BPA procedure
Experimental group:Traditional simple BPA + thrombotic tissue removal
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 18-80 years; 2. CTEPH patients with definite diagnosis: after more than 3 months of standardized anticoagulant therapy, chronic pulmonary artery thrombosis was confirmed by imaging, and mPAP >= 25mmHg and PAWP <= 15mmHg were confirmed by right cardiac catheterization, except for other similar embolic diseases, such as vasculitis, pulmonary artery sarcoma, fibrinoid mediastinum, congenital pulmonary artery stenosis, etc.; 3. Comply with any of the following standards: (1) Pulmonary endarterectomy (PEA) cannot be performed due to contraindication; (2) Not suitable for pulmonary endarterectomy (PEA); (3) Persistent or recurrent pulmonary hypertension after receiving PEA. 4. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe heart failure or grade IV heart function; 2. severe systemic infection or fever; 3. Severe renal insufficiency; 4. Severe anemia or active bleeding; 5. Patients who cannot tolerate anticoagulant therapy; 6. People who are mentally ill and cannot cooperate with the operation; 7. People allergic to iodine contrast agent; 8. Participated in any other experiment within 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary Angiography Pulmonary Flow Grading (PFG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral oxygen saturation;NT-proBNP;6 minutes walking distance (6MWD);Chest radiograph and lung CT;Echocardiography;Right cardiac catheter hemodynamic data (PAP, RAP, PAWP, PVR, CI, CO, SvO2);Histopathological examination of aspiration thrombus; | — |
Countries
China
Contacts
Public ContactGuo Tingting, Hua Lu
Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed