Effects of P-V curve based lung protective ventilation strategy combined with PCV-VG on cerebral oxygen saturation and rehabilitation indicators in elderly patients with one-lung ventilation

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100052547

Enrollment

Unknown

Registered

2021-10-30

Start date

2021-10-29

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive dysfunction after lung cancer surgery

Interventions

experimental group:Volume control pressure assurance + lung protective ventilation

control group:Modes of ventilation

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. ASA I-II; 2. The cardiopulmonary function is basically normal and can tolerate single-lung ventilation; 3. Thoracoscopic operation lasted more than 60 minutes; 4. Understand and agree to sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to surgery and anesthesia; 2. Patients with anaesthetic drug allergy; 3. Patients with severe coronary atherosclerotic heart disease, metabolic disease, and severe liver and kidney function injury; 4. The preoperative MMSE score exceeded the lowest score of the corresponding education level; 5. Difficult airway; 6. Drug addiction and mental illness.

Design outcomes

Primary

Measure	Time frame
Cerebral Oxygen Saturation;Mini-mental State Examination score;	—

Countries

China

Contacts

Public ContactSun Jianhong

Affiliated Hospital of Yangzhou University

jianhongsun@163.com+86 13605277966

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026