Postpartum depression
Conditions
Interventions
experimental group 1:Esketamine 0.25mg/kg iv
experimental group 2:Esketamine 0.5mg/kg iv
control group:NS 10ml iv
Sponsors
Chengdu Women and Children's Central Hospital
Eligibility
Sex/Gender
Female
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 25 to 35 years for cesarean section under general anesthesia; 2. ASA I-II; 3. Weight 60-85kg, singleton, gestational age 37-41 weeks; 4. One day before the operation, the maternal was evaluated by the depression Self-rating Scale, and the score was <0.6 5. Mallampati I-III; 6. Ultrasound examination showed that the fetus was developing normally.
Exclusion criteria
Exclusion criteria: 1. Patients with difficult airway, heart function grade III or above, complicated with serious lung disease; 2. Long-term use of narcotic analgesics, sedatives or non-steroidal anti-inflammatory drugs; 3. Patients with contraindications to general anesthesia; 4. Patients who are allergic to any of the investigational drugs; 5. Patients with contraindications for experimental drugs were satisfied; 6. Participated in drug clinical trials as a subject within the last 3 months; 7. Patients with cognitive dysfunction or mental or neurological dysfunction unable to match the pain score.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh score; | — |
Countries
China
Contacts
Public ContactLi Weina
Chengdu Women and Children's Central Hospital
Outcome results
None listed