Mild Cognitive Impairment
Conditions
Interventions
DLPFC group:active rTMS target DLPFC
PPC group:active rTMS target PPC
DLPFC+PPC group:active rTMS target DLPFC and PPC
Sponsors
Department of Neurology, Tongji Hospital, School of Medicine, Tongji University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Right-handed, Chinese aged 50-85 years; 2. Voluntarily sign the informed consent; 3. Patients diagnosed with MCI; 4. Reach the safety standard of rTMS treatment.
Exclusion criteria
Exclusion criteria: 1. Those who have severe vision, hearing, aphasia and other physical diseases and cannot successfully complete the neuropsychological test; 2. Have other clear history of neurological or psychiatric diseases (such as dementia, stroke, Parkinson's disease, major depression, etc.), cardiovascular disease, diabetes, thyroid disease, vitamin B12 deficiency or history or evidence of drug abuse; 3. History of continuous use of any drugs that may affect cognitive function within the past 1 month; 4. Structural magnetic resonance imaging indicates the presence of new lesions or space-occupying lesions; 5. The relevant questionnaire scores meet the following standards: Hamilton Depression Scale (HAMD-17) score >= 17, Hamilton Anxiety Scale (HAMA-14) score >= 14, Apathy Scale (AES-S) score >= 30, Pittsburgh Sleep Quality index (PSOI) scale >= 16, life events scale (LES) score > 20.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral expression of emotion regulation paradigm;Emotional regulation task EEG; | — |
Countries
China
Contacts
Public ContactLi Yunxia
Department of Neurology, Tongji Hospital, School of Medicine, Tongji University
Outcome results
None listed