Postpartum depression
Conditions
Interventions
Group A:Adjunctive application of esketamine during cesarean section
Group B:Adjunctive application of saline during cesarean section
Sponsors
Maternity Hospital Affiliated to Nanjing Medical University (Nanjing Maternal and Child Health Hospital)
Eligibility
Sex/Gender
Female
Age
19 Years to 45 Years
Inclusion criteria
Inclusion criteria: Singleton, full-term, elective cesarean delivery under simple lumbar anesthesia.
Exclusion criteria
Exclusion criteria: Age 45 years, hypertension, cardiac insufficiency, glaucoma, central nervous system disease, fetal malformation, HIV infection, anti-inflammatory or antidepressant medication within 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative EPDS depression score;Postoperative EPDS depression score;Postoperative EPDS depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;number of births;Gestational week;BMI;History of chronic pain;Indications for surgery;duration of surgery;intraoperative blood loss;blood loss 24 hours after surgery;The expression level of IL-6 in cerebrospinal fluid before operation;The expression level of IL-10 in cerebrospinal fluid before operation;Expression level of TNF-a in preoperative cerebrospinal fluid;Postoperative incision pain;Postoperative uterine contraction pain;Doses administered by analgesic pump;Number of PCA usage;Postoperative drug concentration in breast milk;Occurrence of maternal and neonatal adverse reactions; | — |
Countries
China
Contacts
Public ContactFeng Shanwu
Maternity Hospital Affiliated to Nanjing Medical University (Nanjing Maternal and Child Health Hospital)
Outcome results
None listed